Associate Professor Zhaolin Hua, Hou Lab, Institute of Biophysics, Chinese Academy of Sciences is visiting Aarhus and will give a SDC/CFIN talk
28.06.2018 |
Dato | tor 09 aug |
Tid | 09:30 — 11:30 |
Sted | Bartholin Building room 1240-211, Læsesal (50), Aarhus University, Bartholin Allé |
Zhaolin Hua
Associate Professor Hou Lab, Institute of Biophysics, Chinese Academy of Sciences
Abstract:
Toll-like receptor (TLR) signaling in B cells plays critical roles in both anti-viral responses and autoimmune diseases. However, the precise mechanism underlying these functions is not clearly understood. B cells mainly express endosomal TLRs, and activation of TLR signaling in B cells largely depends on B cell receptor (BCR)-mediated antigen uptake in vivo. Thus, functions of TLR signaling in B cells often occur in the context of B cell activation. To study TLR signaling in B cells, we used bacterial phage Qβ-derived virus-like particle (Qβ-VLP) as a model antigen and developed methods to label and enrich Qβ-specific B cells. By examining antigen-specific B cell response to Qβ-VLP, we found that TLR signaling in B cells promoted multiple aspects of antibody responses through promoting early B cell proliferation and expression of transcription factors involved in cell differentiation.
References:
ALL ARE WELCOME
For more information, please contact Kim Ryun Drasbek: ryun@cfin.au.dk