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Guest lecturer Prof. William Edward Louch, Institute for Experimental Medical Research, University of Oslo, Norway: "Understanding the Heartbeat at the Nanoscale".
22.02.2019 |
| Dato | tor 02 maj |
| Tid | 09:00 — 10:15 |
| Sted | The anatomical lecture theatre, build. 1232, room 115 |
This is an invitation to the first seminar within the “Membranes” research theme.
We are happy to host Prof. William Edward Louch from the Institute for Experimental Medical Research, University of Oslo, Norway.
Host: Dr. Vladimir Matchkov, Department of Biomedicine, AU.
Abstract
Contraction of the heart is reliant on the shortening of individual cardiomyocytes, which is triggered by Ca2+ release from the sarcoplasmic reticulum (SR). This Ca2+ release process is initiated at sub-cellular structures called dyads, where L-type Ca2+ channels within t-tubules face Ryanodine Receptors in the SR. Despite the fundamental role of dyads in triggering the heartbeat, their precise functional arrangement remains unclear. In the present work, emerging techniques for 3D super-resolution imaging and electron microscopy have been employed to reveal the nanoscale arrangement of key dyadic proteins and membranes. This work has shown that dyadic structure and function are highly malleable. Indeed, during development, dyads are formed gradually, with progressive assembly of both t-tubules and SR and precise trafficking of L-type Ca2+ channels and Ryanodine Receptors. During diseases such as heart failure, dyads are broken down with a reversion to an immature phenotype, including both disorganization of t-tubules and dispersion of RyRs which reduces the efficiency of Ca2+ release. Understanding the signals that control dyadic structure/function thus presents a therapeutic opportunity to strengthen the heartbeat in cardiac patients.
Best wishes,
Søren Brandt Poulsen
Membranes