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New publication in Neurobiology of Aging

A new study by the Two-Photon group at CFIN investigated the hemodynamic changes in the brain cortex of an animal model of Alzheimer’s disease.

15.11.2017 | Henriette Blæsild Vuust

First author Eugenio Gutiérrez-Jiménez, CFIN

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This analysis was also performed in a group of aged mice. By using in-vivo two-photon microscopy the group found that the transgenic mice showed low levels of cortical perfusion during steady state. They also found that both, transgenic and aged mice, showed hemodynamic disturbances during steady state and functional activation.

The group proposes that capillary dysfunction during rest and functional activation, could be a biomarker of age-related changes in brain oxygenation.

The results of the study, Disturbances in the control of capillary flow in an aged APPswe/PS1ΔE9 model of Alzheimer's disease, is published in Neurobiology of Aging.

Read more:
https://www.sciencedirect.com/science/article/pii/S0197458017303457

Read more about the TPML at CFIN:
http://cfin.au.dk/cfinmindlab-labs-research-groups/tpml-two-photon-microscopy-laboratory/

Forskning, Sundhed og sygdom, Videnskabelig medarbejder, CFIN, CFIN, Ph.d.-studerende, Forskningsårsstuderende, Udvekslingsstuderende, Kommende studerende

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Revideret 20.05.2022 - 
Henriette Blæsild Vuust