PhD defense: Hugo Angleys

PhD student at CFIN Hugo Angleys is defending his PhD thesis on "The role of capillary transit time heterogeneity on oxygen and glucose extraction in the brain".

29.03.2017 | Henriette Blæsild Vuust

Dato man 15 maj
Tid 12:30 15:00
Sted The lake Side Auditoriums (Søauditorierne) - Jeppe Vontillius Auditorium (Building 1252, room 310)


Title of the thesis:

The role of capillary transit time heterogeneity on oxygen and glucose extraction in the brain.

Abstract:

The brain’s high resting metabolism is fueled almost entirely by oxidative phosphorylation of glucose, and normal brain function is therefore contingent on a steady supply of oxygen and glucose. Getting a better understanding of the mechanisms controlling this supply is therefore of foremost importance.

It was proposed 25 years ago that not only the blood flow, but also its pattern plays an important role to regulate tissue oxygenation. This hypothesis was supported by several experimental studies suggesting that the blood flow is actively redistributed at the capillary level.

In this thesis, based on biophysical modeling, we further examine the effects of capillary flow pattern on oxygen and glucose delivery. We show that homogenization of capillary flow is an effective means to increase oxygen availability. Employing our model to predict the blood-oxygen-level dependent (BOLD) signal, we show that our predictions are consistent with neuro-capillary coupling mechanisms, i.e. homogenization of capillary flows to increase oxygen availability.

Overall, this project emphasizes the importance of capillary flow patterns on oxygen and glucose delivery to cerebral tissues, and provides a framework to evaluate the role of the microcirculation in health and disease.

ALL ARE WELCOME.

 

The defense will be held in the Jeppe Vontilius Auditorium at Aarhus University.
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Ph.d.-forsvar, Sundhed og sygdom, Videnskabelig medarbejder, CFIN, CFIN, Ph.d.-studerende, Musicinthebrain, Forskningsårsstuderende, Studerende