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Lecturer Ina Maria Schiessl: "Tracking renal cell regeneration in vivo and over time using serial intravital 2-photon microscopy"
13.12.2019 |
| Dato | ons 05 feb |
| Tid | 12:00 — 13:00 |
| Sted | Ll. Anat. aud. |
Abstract
Chronic kidney disease (CKD) is a severe medical condition involving gradual loss of kidney function, which eventually leads to kidney failure and is commonly caused by hypertension, diabetes or incomplete recovery from acute kidney injury. There is an unmet need for novel treatment strategies for CKD, which is hampered by an incomplete understanding of renal regenerative mechanisms. Thus, kidney regeneration is classically studied using static histological techniques on tissue samples derived from different animals and time points, which may fail to correctly reconstruct the complex and dynamic intercellular interactions during tissue remodeling. Recently established serial intravital 2-photon microscopy of the kidney is a powerful technique to study renal structure and function simultaneously and allows the tracking of individual cell fate over several weeks based on paired observations. Here, I will present how this technique can be used to study novel mechanisms of renal tubule and endothelial cell regeneration.
You do not have to sign up for the seminar, walk-ins are of course welcome, but please note that the deadline for sandwich sign-up is on Monday the 3rd of February.
We hope to see you at Ina’s talk next week!
The Biomedicine seminar organizing committee
Line Reinert
Martin Thomsen
Søren Degn
Mikkel Vendelbo