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Lecturer Karthika Rajeeve: "Metabolic reprogramming: A central role of Glutamine in Chlamydia infection"
13.12.2019 |
| Dato | ons 03 jun |
| Tid | 12:00 — 13:00 |
| Sted | Zoom ID: 699 1952 3577 |
Abstract
The obligate intracellular bacterial pathogen Chlamydia trachomatis is the most frequent bacterial agent of sexually transmitted diseases, infertility, and blindness. It undergoes a complex developmental cycle between infectious non-replicative (EBs) and non-infectious replicative (RBs) forms. EBs shortly after entering a host cell transform to RBs, a crucial process in infection, initiating chlamydial replication. As Chlamydia fail to replicate outside the host cell it is currently unknown how the transition from EBs to RBs is initiated. Metabolic flux analysis reveals the critical role of glutamine in the establishment of the pathogen. The bacteria metabolically reprogram host cell to facilitate glutamine uptake and generates glutamine addiction. Interference with this metabolic reprogramming limited growth of Chlamydia, thus providing a basis for innovative anti-infective strategies.
Our lab aims to advance the understanding of molecular determinants of host-pathogen interactions and to develop novel innovative strategies for combatting infectious diseases.
Join Zoom Meeting
https://aarhusuniversity.zoom.us/j/69919523577
Meeting ID: 699 1952 3577
The Biomedicine Seminar Organizing Committee
Line Reinert
MartinThomsen
Søren Degn
Mikkel Vendelbo