Peter Parbo, MD, Department of Nuclear Medicine & PET Centre will defend his PhD thesis on: "A PET study of the relationship between microglial activation amyloid-β plaques and tau tangles in early Alzheimer’s disease"
19.01.2018 |
Dato | man 05 feb |
Tid | 14:00 — 16:30 |
Sted | Pathology Auditorium, Aarhus University Hospital, Nørrebrogade 44, bldg.18 |
Peter Parbo, MD
Department of Nuclear Medicine & PET Centre
Title: A PET study of the relationship between microglial activation amyloid-β plaques and tau tangles in early Alzheimer’s disease
Summary:
Alzheimer’s disease is the most common cause for dementia affecting more than 50,000 people in Denmark. Alzheimer's disease is a neurodegenerative disease leading to cognitive and behavioural dysfunctions. The aim of this thesis was to examine the inter-relationships between levels and distributions of amyloid plaques, tau tangles and microglial activation, using 11C-PiB, 18F-flortaucipir and 11C-PK11195 positron emission tomography (PET) in prodromal and early clinical Alzheimer’s disease. The cohort is being followed and assessed again after a 2 year interval. Our baseline findings provide in vivo evidence that brain inflammation is an early event in Alzheimer’s disease. Hence, an intervention targeting microglial activation could play a neuroprotective role against Alzheimer’s disease.
Main supervisor: Professor David Brooks, Dept. of Nuclear Medicine & PET Centre, Aarhus University
Chairman: Professor Henning Andersen, Dept. of Neurology, Aarhus University
Examiners:
The defense is public and all are welcome!
For more information, please contact MD PhD student Peter Parbo, e-mail: parbo@au.dk