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Seminar: Animal model of Peritoneal Dialysis for studies of peritoneal capillary blood flow and fibrosis usingmulti-photon microscopy

Peritoneal dialysis is a renal replacement therapy. The thickness of the peritoneal membrane and the collagen layer are known to be markers of peritoneum dysfunction. This study aims to develop a method based on multi-photon microscopy to study the functioning of the peritoneal membrane during dialysis exchange.

25.10.2021 | Health Kommunikation

Dato tir 26 okt
Tid 13:15 14:00
Sted Building 1231, room 114 "Kollokvierummet"

Experimental models with fibrotic peritoneum using high osmolality solutions are reproducible in terms of an increase in the parameters of cellularity, vascularization, fibrosis and thickening of collagen fibers. Oleuropein, a molecule extracted from olive leaves, has protective effects on the membrane.

The developed method has potential for a dynamic and reliable in vivo approach.Studies are ongoing to validate the effects of drugs and dialysates with different osmotic and electrolytic compositions on the dialysis capacities of the peritoneal membrane and on the blood flow in peritoneal capillaries.

About the speaker:
Luciano D'Apolito will finish his Ph.D. at University of Campania "Luigi Vanvitelli, Naples" in spring 2022 and is visiting Department of Biomedicine (group of Sebastian Frische), AU, until Christmas 2021.

Seminar, Videnskabelig medarbejder, Health, Health, Ph.d.-studerende, Institut for Biomedicin, Forskningsårsstuderende