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Lecturer Joanna Kalucka: "Metabolic and transcriptomic heterogeneity of endothelial cells"
2019.12.13 |
| Date | Wed 01 Apr |
| Time | 12:00 — 13:00 |
| Location | Zoom meeting ID: 286 884 481 |
The seminar will be held online via Zoom at:
https://aarhusuniversity.zoom.us/j/286884481
Meeting ID: 286 884 481
Abstract
Blood vessels ensure nutrient and oxygen supply to all cells via transport thought the endothelium. The endothelial cell (EC) layer lining the luminal side of blood vessels forms a selective interface between the circulating blood and the surrounding tissue. ECs display high plasticity: i.e. in health, ECs established blood vessels are quiescent and rarely divide but upon stimulation in pathological conditions, they switch to a proliferative state and can migrate to form new sprouts.
Each tissue in our body has its own vascular bed that helps to carry out its distinctive and versatile functions. The anatomical classification of blood vessels into arteries, capillaries and veins, and morphological grouping of ECs into barrier – forming continuous ECs, fenestrated ECs and sinusoidal ECs has long been recognized. Nevertheless, the functional properties and underlying molecular mechanisms of these specialized vasculatures have only started to be uncovered recently. The approaches on how to decipher ECs heterogeneity, e.g. by single cell RNA sequencing, will be presented during the seminar.
Biomedicine seminar organizing committee
Line Reinert
Martin Thomsen
Søren Degn
Mikkel Vendelbo