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Biomedicine Seminar - via Zoom

Lecturer Samia Joca: "Glutamate and beyond: in the search for better therapeutics in depression"

2021.01.04 | Zitta Glattrup Nygaard

Date Wed 03 Mar
Time 12:00 13:00
Location Zoom Meeting ID: 680 3666 2438


Although currently available antidepressants are effective, they all have a substantial time lag to induce a significant therapeutic response. Additionally, approximately 40% of the patients do not reach remission after several weeks of treatment. Therefore, the development of drugs that address these limitations is critical to improving public health.

Clinical and preclinical research published in the last decade has consistently shown that drugs that modulate glutamatergic signaling in the brain are potential fast-acting antidepressants. However, they induce side-effects that limit their use. The discovery of new drugs that indirectly modulate glutamatergic signaling, acting as rapid antidepressants without inducing significant side effects, is therefore of great importance. In this scenario, purinergic, nitrergic and endocannabinoid signaling can be of potential interest since they modulate glutamate release in import limbic brain regions related to depression neurobiology. In this talk, I will present some of the newest evidence from our group that supports the search for better antidepressants by targeting atypical neurotransmitters (NO and endocannabinoids) and purines.

The seminar will be held online via Zoom Meeting


Meeting ID: 680 3666 2438

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Meeting ID: 680 3666 2438

The Biomedicine Seminar Series Organizing Committee

Line Reinert 
Martin Thomsen 
Søren Degn 
Mikkel Vendelbo

Seminar, Research, Public/Media, Health, Department of Biomedicine, PhD students, Department of Biomedicine, Technical / administrative staff, Academic staff