Children born to mothers who have diabetes before becoming pregnant or during her pregnancy have a greater risk of heart diseases later in life. This is shown by research from Aarhus University and Aarhus University Hospital. Prevention and treatment for those women at childbearing ages can help to reduce this risk.
2020.01.09 |
If a mother has diabetes before becoming pregnant or during her pregnancy, her offspring risk being affected by heart diseases higher than children of mothers without diabetes. This is the conclusion of a study from AU and AUH which has just been published in the scientific journal BMJ.
”The risk of cardiovascular disease was increased in each age group in childhood before the age of twenty also and in early adulthood between the ages of twenty and forty, regardless of whether the children were ‘exposed’ to pregestational diabetes (type 1 or type 2 diabetes), or gestational diabetes,” explains Yong Fu, who has carried out the study together with Jiong Li.
The risk was particularly pronounced among the children of mothers who currently or previously had cardiovascular disease or complications in connection with their diabetes.
The findings are based on data from more than 2.4 million children without congenital heart disease who were born in Denmark between 1977 and 2016. During the course of up to forty years of follow-up, the children of mothers with diabetes had a 29 per cent higher risk of an early 'onset' of cardiovascular disease compared to the children of mothers who had not had diabetes.
The number of women with diabetes before or during pregnancy has risen globally, and the children of these women are thus more likely to be in the risk group for cardiovascular diseases such as high blood pressure and high blood sugar levels.
“The findings underline the importance of effective strategies for screening and preventing diabetes in women of childbearing age – not only to improve the health of these women but also to reduce the long-term risk of cardiovascular diseases among their children," says Jiong Li.
The researchers categorised diabetes as before or during pregnancy, while at the same time identifying those women who had complications in connection with their diabetes. Other important factors such as age, education, and lifestyle (smoking during pregnancy) were also taken into account.
Jiong Li mentions that the study, which is a population-based cohort study, may not establish a direct causal relationship.
"We can’t rule out the possibility that some of the findings may be attributed to other unmeasured factors. However, the study’s strength is the extensive data material, the long follow-up period of up to forty years, and the fact that we arrived at the same results after further consideration of un-observed genetic or familial factors” explains Jiong Li.
PhD, MSc, Postdoc Yongfu Yu
Department of Clinical Epidemiology, Department of Clinical Medicine, Aarhus University and
Aarhus University Hospital
Mobile: (+45) 7131 6566
yoyu@clin.au.dk
PhD, Associate Professor Jiong Li
Department of Clinical Epidemiology, Department of Clinical Medicine, Aarhus University and
Aarhus University Hospital
Tel: (+45) 8716 8401
jl@clin.au.dk