The more weeks a women takes pain-reliving medication during pregnancy, the earlier their daughters enter puberty. This is shown by a new study from Aarhus University.

2018.10.18 | Helle Horskjær Hansen

Breasts, pimples and menstruation, hair growth in places where there was none previously, and unpredictable mood swings. Welcome to puberty, which for the majority of girls begins when they are around ten or eleven years old – or even earlier – if the mother has taken painkillers with paracetamol (which in Denmark sell under names such as e.g. Panodil, Pinex or Pamol) during pregnancy.

As the first in the world, researchers from Aarhus University have examined the correlation between the intake of the analgesic paracetamol during pregnancy and girls and boys pubertal development. The results have just been published in the international journal, American Journal of Epidemiology.

"We found a ‘dose-response’ correlation. That is to say, the more weeks with paracetamol during pregnancy, the earlier puberty in girls, but not in boys," says PhD student Andreas Ernst from the Department of Public Health, Aarhus University, who is behind the study.

The study is based on the largest collection of puberty data in the Danish birth cohort (BSIG.dk). A group of around 100,000 women provided detailed information about their use of paracetamol three times during their pregnancy. A total of 15,822 children, 7,697 boys and 8,125 girls born to these mothers between 2000-2003 were followed from the age of eleven and throughout puberty with questionnaires every six months about several different aspects of their development.

Puberty arrives earlier

The study showed that girls on average enter puberty between one-and-a-half and three months earlier, if the mother took painkillers for more than twelve weeks during pregnancy.

"While entering puberty one-and-a-half to three months earlier may seem unimportant, when taken together with the frequent use of paracetamol during pregnancy, our findings ought to make people take notice. Our results are certainly not the decisive factor that should change current practice, but the perception of paracetamol as ‘the safe and harmless choice’ during pregnancy ought to be challenged," explains Andreas Ernst.

Worldwide, the average consumption of paracetamol has been increasing, and studies suggest that more than fifty per cent of pregnant women make use of painkillers containing paracetamol at least once during their pregnancy.

"As earlier pubertal development has previously been tied to an increased risk of more frequent and serious diseases in adulthood such as obesity, diabetes, cardiovascular diseases and testicular and breast cancer, it’s important to identify possible causes of early puberty so we can prevent this development," says Andreas Ernst.

The research results - more information

The study is an epidemiological cohort study.

The project is financed by: A Sapere Aude grant from the Danish Council for Independent Research and the Faculty of Health, Aarhus University.

The partners involved in the project are: Cecilia H. Ramlau-Hansen, Nis Brix, Lea L. B. Lauridsen and Jørn Olsen from Aarhus University, Department of Public Health, Epidemiology; Erik T. Parner from Aarhus University, Section for Biostatistics; Zeyan Liew from Fielding School of Public Health, Department of Epidemiology, University of California Los Angeles, USA; and Lars H. Olsen from Aarhus University Hospital, Department of Urology.

Read the article : Acetaminophen (Paracetamol) Exposure during Pregnancy and Pubertal Development in Boys and Girls from a Nationwide Puberty Cohort

Contact

PhD student Andreas Ernst
Aarhus University, Department of Public Health
Tel.: (+45) 2398 6181
aernst@ph.au.dk