Professor Chris Meisinger: “Signalling pathways targeting the mitochondrial import machinery: control of cell cycle, metabolism and oncogenesis“ and Dr. Nora Vögtle: “Quality control by the mitochondrial presequence processing machinery in health and disease”, ZBMZ, Institute of Molecular Medicine and Cell Research, Faculty of Medicine, University of Freiburg, Germany

2019.04.10 | Zitta Glattrup Nygaard

Abstract 
Professor Chris Meisinger: Mitochondria have to import more than 1000 different proteins from the cytosol to fulfill a multitude of functions. Sophisticated import machineries mediate targeting, translocation and suborganellar sorting. They have been considered for a long time to be static and constitutively active. However, we found that the protein entry gate of the outer membrane is highly phosphorylated and targeted by several cytosolic signalling cascades that dynamically regulate protein import to adjust the mitochondrial proteome to changing cellular demands. These include metabolic switches, various cell cycle stages and metabolic reprogramming during oncogenesis.  

Abstract 
Dr. Nora Vögtle: The mitochondrial presequence processing machinery plays an essential role in protein biogenesis and proteostasis: the proteases cleave N-terminal targeting peptides for protein maturation, remove destabilizing residues to increase the half-life and degrade toxic cleaved presequences. Their dysfunction results in an imbalanced mitochondrial proteome and mutations have been linked to neurodegeneration and cardiomyopathy. We have identified novel components and functions of these proteases and now investigate the impact of disease-related mutations on mitochondrial function and metabolism in human cells.  

If you wish to meet the speakers in the afternoon after 14.00, individually or in groups, please contact Marianne Rasmussen mr@biomed.au.dk and Poul Henning Jensen phj@biomed.au.dk.

Programme

Hosted by Poul Henning Jensen
Organized by Marianne Rasmussen
Department of Biomedicine, Neuroscience