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The paper explores the effects of ligands to metabotropic glutamate receptors (mGluRs) at synapses of the human cerebral cortex as potential novel drugs for neurological and psychiatric disorders.
2019.01.10 | Frederikke Schmidt-Kallesøe
The paper shows the effects of group II mGluR activation on excitatory synaptic transmission recorded from pyramidal neurons of cortical layers 2–3 in acute slices derived from surgically removed cortical tissue of people with epilepsy or tumors. Therefore, this paper suggests for the first time potential mechanisms by which an mGluR drug could exert pro-cognitive effects and treat human neuropsychiatric disorders. This work is part of an ERC-funded collaboration between Marco Capogna, Aarhus University, and Peter Somogyi (Brain Prize winner 2011), Oxford.
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