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In collaboration with their colleagues from Brazil, TNU researchers Rodrigo Grassi-Oliveira and Rodrigo Orso have just published the article "Sex differences in risk behavior parameters in adolescent mice: Relationship with brain-derived neurotrophic factor in the medial prefrontal cortex"
2021.11.12 |
The sex distinctions regarding risk aversion/assessment and risk exposure behaviors suggest that females present a pattern of greater risk aversion/assessment and anxiety response to potentially threatening and anxiety-eliciting situations.
Moreover, the alterations in BDNF exon IV expression highlights the importance of exploring and associating sex-dependent behavioral specificities and biomolecular markers. This could lead to the understanding of susceptibility patterns that culminate in sex-specific dysfunctions.
In addition, periods such as adolescence may represent windows of opportunity for the investigation of sex differences, since several neurodevelopmental and hormonal alterations are occurring throughout this period, which could be related with the differences in decision making processes and stress-related responses.
Marco G.S. Gomes, Saulo G. Tractenberg, Rodrigo Orso, Thiago W. Viola, Rodrigo Grassi-Oliveira
Neuroscience Letters, Volume 766, 2022
Contact
Associate Professor
Rodrigo Grassi-Oliveira
Translational Neuropsychiatry Unit
Department of Clinical Medicine
Universitetsbyen 13
8000 Aarhus C