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Active parts of the brain require an increased delivery of oxygen and nutrition as well as waste product removal. This autoregulation is ensured by precise communication between neuronal tissue and the vasculature, i.e., neurovascular coupling.
2021.07.01 |
NSD21 Poster Prize winner Christian Staehr
Christian Staehr, MD and PhD student in Vladimir Matchkov’s research group at Dept. of Biomedicine, Aarhus University, aims to improve our understanding of neurovascular coupling. Within the last decades, it has become apparent that disturbances in neurovascular coupling are involved in a variety of neurological disorders including migraine, stroke, traumatic brain injury, and Alzheimer’s disease. Christian Staehr believes that detailed insight into cell-to-cell communication between neurons and arterioles may improve future treatment options of these neurological disorders. One of the major discoveries in Christian Staehr’s PhD project is that unbalanced potassium signalling between neuronal tissue and cerebral vessels disturbs neurovascular coupling in familial hemiplegic migraine. This work was recently published in Cardiovascular Research.1 Christian Stæhr was assigned the Zeiss Poster Prize for his outstanding presentation of this significant finding at Neuroscience Day 2021 “Flowing Neuroscience”.
1. Staehr C, Rajanathan R, Postnov DD, et al. Abnormal neurovascular coupling as a cause of excess cerebral vasodilation in familial migraine. Cardiovasc Res. 2020;116(12):2009-2020.