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Clinical consequences of acromegaly
2021.08.18 |
| Date | Fri 27 Aug |
| Time | 10:00 — 12:00 |
| Location | Auditorium J116, Aarhus University Hospital, Entrance J, level 1, 99 Palle Juul-Jensens Boulevard |
On Friday 27 August at 10.00, Mai Christiansen Arlien-Søborg defends her PhD dissertation entitled "Clinical consequences of acromegaly: Body composition, insulin sensitivity and protein metabolism".
Growth hormone (GH) is essential for postnatal growth and exerts important protein anabolic effects in adulthood, which is mainly mediated by IGF-I in the presence of energy substrate abundance. During short and long-term fasting, GH stimulates lipolysis and this ability to promote either protein anabolism or lipid catabolism depending on energy balance is likely to contribute to metabolic flexibility. During pathophysiological conditions of sustained GH excess, however, GH induces insulin resistance, which is linked to the lipolytic actions. Additional mechanisms may contribute and the molecular mechanisms remain incompletely understood. In the current thesis, the metabolic consequences of long standing GH excess with a particular emphasis on lipolysis, insulin sensitivity and protein metabolism are investigated.
The summary is written by the PhD student.
The defence is public and takes place in Auditorium J116, Aarhus University Hospital, Entrance J, level 1, 99 Palle Juul-Jensens Boulevard, DK-8200 Aarhus N. Please read the attached press release for more information.
PhD student Mai Christiansen Arlien-Søborg
Mail: mas@clin.au.dk
Phone: (+45) 23837420