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Histological profiling of tumor microenvironment in colorectal cancer
2020.09.18 |
| Date | Fri 09 Oct |
| Time | 09:00 — 11:00 |
| Location | Auditorium, Entrance B, Skovlyvej 9, Randers Hospital and online via Zoom |
Friday 9 October at 9:00, Margarita Melnikova Jørgensen defends her PhD dissertation entitled “Histological profiling of tumor microenvironment in colorectal cancer”.
Colorectal cancer (CRC) is the third most common cancer form worldwide. Tumors within the same pathoanatomical group often vary in prognosis and treatment response because of an underlying molecular and biological heterogeneity of CRC. Therefore, there is a need to complement tumor staging with new prognostic biomarkers. The tumor microenvironment consisting of cells surrounding the tumor has recently been highlighted as a novel determinant of disease progression. The tumor microenvironment plays a dual role in tumorigenesis, either acting as a tumor enhancer or tumor inhibitor, depending on its cellular composition.
The main objective of this PhD study is to characterize tumor microenvironment using a panel of clinically relevant histological markers. In this project the relationship between the tumor microenvironment and molecular/biological profile of CRC is investigated using immunohistochemistry and automated digital image analysis software (Visiopharm). Another aspect of the study adresses the application of tissue microarrays in biomarker studies followed by the validation of this technique for our biomarker panel. Additionally, the relationship between epithelial and stromal compartments of CRC and examination of CDX2 loss in relation to the clinicopathological parameters are investigated.
The summary is written by the PhD student.
The defence is public and will be held in Auditorium, Entrance B, Skovlyvej 9, Randers Hospital and online via Zoom. Please read the attached press release for more information.
PhD student Margarita Melnikova Jørgensen
Mail: msm@clin.au.dk
Tel.: (+45) 2025 8333