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PhD defence: Marie Vognstoft Hjortbak

Disparity in the cardioprotective efficacy of ischemic conditioning strategies against myocardial ischemia reperfusion injury - Interaction with age, diabetes, aerobic capacity and antithrombotic treatment

2021.06.09 | Graduate School of Health

Date Fri 02 Jul
Time 13:00 15:00
Location Auditorium A, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N

On Friday 2 July at 13:00, Marie Vognstoft Hjortbak defends her PhD dissertation entitled "Disparity in the cardioprotective efficacy of ischemic conditioning strategies against myocardial ischemia reperfusion injury - Interaction with age, diabetes, aerobic capacity and antithrombotic treatment".

During a heart attack and the following reperfusion treatment by angioplastry, a complicated interplay of cellular mechanisms contribute to the final myocardial injury. The myocardial injury can be targeted by a treatment strategy called ischemic conditioning, which consists of brief episodes of ischemia and reperfusion prior to or during a lethal period of ischemia in the heart. Ischemic conditioning effectively reduces ischemia and reperfusion injury in the heart, however the method is sensitive to factors such as high age, comorbidity and comedication. This PhD project has used both rats and human data to investigate the interaction between ischemic conditioning and age, type 2 diabetes mellitus, aerobic capacity and antithrombotic medications. The interactions found may all contribute to a succesfull translation of ischemic conditioning to humans suffering from a heart attack.   

The summary is written by the PhD student.   

The defence is public and takes place in Audotorium A at Aarhus University Hospital, Palle Juul-Jensens Boulevard, Aarhus N. Please read the attached press release for more information.

Contact:

PhD student Marie Vognstoft Hjortbak

Mail: hjortbak@clin.au.dk

Phone: (+45) 22848452

Read full press release

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