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Characterization of genetic variation and cyst membrane protein expression in autosomal dominant polycystic kidney disease with potential impact on prognosis and treatment
2021.09.23 |
| Date | Fri 15 Oct |
| Time | 14:00 — 16:00 |
| Location | Auditorium A (1162-013), Aarhus University, Ole Worms Allé 4, 8000 Aarhus C |
On Friday 15 October at 14:00, Marlene Louise Nielsen defends her PhD dissertation entitled "Characterization of genetic variation and cyst membrane protein expression in autosomal dominant polycystic kidney disease with potential impact on prognosis and treatment".
The autosomal dominant form of cystic kidney disease is called ADPKD. It is characterized by development and growth of fluid filled kidney cysts that damage the kidney tissue resulting in a decrease in kidney function and possibly kidney failure. Presently, no treatment able to cure ADPKD exists, but medical drugs are able to delay progression of the disease for some years. To increase the quality of life in patients and reduce the costs for society it will be essential to improve prediction of disease progression as well as to increase the effect and reduce the side effects of potential treatment. The overall aim of this PhD-dissertation from Aarhus University, Health, was to examine the disease causing gene defects in Danish ADPKD-patients, the prognostic value of genetic markers and the potential of the kidney protein megalin to increase the uptake in kidney cysts of potential medical drugs able to slow cyst growth.
The summary is written by the PhD student.
The defence is public and takes place in Auditorium A (1162-013), Aarhus University, Ole Worms Allé 4, 8000 Aarhus C. Please read the attached press release for more information.
PhD student Marlene Louise Nielsen
Mail: marlene.n@biomed.au.dk
Phone: (+45) 24612359