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PhD defence: Tingting Gu

Do conditioned extracellular vesicles protect brains from ischemic injury? – proof from a murine stroke model

2021.06.09 | Graduate School of Health

Date Thu 17 Jun
Time 10:00 12:00
Location Samfundsmedicinsk Auditorium 1262-101, Bartholins Allé 4, 8000 Aarhus C

On Thursday 17 June at 10.00, Tingting Gu defends her PhD dissertation entitled "Do conditioned extracellular vesicles protect brains from ischemic injury? - proof from a murine stroke model".

Stroke is a severe brain disease that can lead to long-term disability and even death. Remote ischemic conditioning (RIC) has been suggested as a promising treatment that is carried out using a blood measure cuff and holds the potential to protect the brain during stroke. Understanding the mechanism by which RIC activates the body’s own defence mechanisms against stroke can help establish the endogenous protective pathways for brain ischemia leading to better treatment. It has been reported that RIC affects the release of the so-called extracellular vesicles (EVs) that are nano sized particles released by many cells.

To test the potential effects of these EVs in protecting the brain from stroke, EVs were isolated from the blood plasma of human subjects before and after RIC treatment and tested in a mouse stroke model. The distribution of these EVs in the ischemic brain, the acute effects on cerebral perfusion and oxygenation, and the prolonged effects of these EVs in neurological function and brain damage were investigated in this PhD project.

The summary is written by the PhD student.     

The denfence is public and is held in Samfundsmedicinsk Auditorium, Aarhus University. Please read the attached press release for more information.

Contact:

PhD student Tingting Gu

Mail: gutt@cfin.au.dk

Phone: (+45) 50197695

Read full press release        

PhD defense, PhD students, Health, Graduate School of Health, Public/Media, Graduate School of Health, Academic staff, Department of Clinical Medicine