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PROMEMO Center Leader, Prof Anders Nykjær is one of the authors of the article: "Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study", which was published in the well-known journal The Lancet Neurology.
2018.05.17 |
PROMEMO Center Leader, Prof Anders Nykjær is one of the authors of the article: "Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study", which was published in the well-known journal The Lancet Neurology.
Frontotemporal dementia is the second most common subtype of neurodegenerative dementia after Alzheimer's disease, and it is characterised by a strong genetic component. Mutations in GRN explain 1–11% of all cases of frontotemporal dementia but age at onset and clinical presentation are variable, even within families. This study identifies a novel genome-wide locus at GFRA2 as a modifier of disease onset and risk in GRN mutation carriers.
Read the full article here.