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In a new paper, Fenghua Chen, Jibrin Danladi, Maryam Ardalan, Connie Sanchez, Gregers Wegener and colleagues show that treatment with two different antidepressants, vortioxetine but not fluoxetine increased the number of microglia and astrocytes accompanied by elevation of Vascular Endothelial Growth Factor. The findings suggest that astrocytes and microglia may have a role in mediating the pharmacological effects of vortioxetine in rats and that these effects are mediated through mechanisms that go beyond inhibition of the serotonin transporter and may target specific 5-HT receptors.
2021.01.08 |
Fenghua Chen
Read the abstract or the full article in European Neuropsychopharmacology
The rat hippocampal gliovascular system following one week vortioxetine and fluoxetine
Chen, Fenghua; Danladi, Jibrin; Ardalan, Maryam; Nyengaard, Jens Randel; Sánchez, Connie; Wegener, Gregers.
In: European Neuropsychopharmacology, Vol. 42, 01.2021.
doi.org/10.1016/j.euroneuro.2020.11.008