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Investigation of SORL1 regulation
2021.06.21 |
| Date | Fri 09 Jul |
| Time | 16:00 — 18:00 |
| Location | Online |
On Friday 9 July at 16:00, Annemarie Svane Aavild Poulsen defends her PhD dissertation entitled "Toward understanding Alzheimer’s disease: An investigation of the regulation of SORL1".
In a new PhD project from Aarhus University, Health, regulation of the Alzheimer's disease (AD) assocated gene SORL1 is investigated.
SORL1 encodes the protein SorLA, of which the expression has been suggested by researchers to protect against AD. It is therefore interesting to investigate how the expression of SorLA is controlled so that we can better understand how an alternative regulation of the gene can cause disease such as AD in the brain.
In the PhD project, the regulation of SORL1 was studied by investigating alternative splicing and how two transcription factors, each of which is important for brain and eye development, could affect the regulation/expression of SORL1/SorLA.
Results show, SORL1 should be regarded as an important gene during both brain and eye development, suggesting that SorLA has also an important function in the eye, in addition to its recognized function in the brain.
The summary is written by the PhD student.
The defence is public and takes place online. Please read the attached press release for more information.
PhD student Annemarie Svane Aavild Poulsen
Mail: am@biomed.au.dk