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Biomarkers in early alpha-synucleinopathies
2021.09.02 |
| Date | Thu 09 Sep |
| Time | 10:30 — 12:30 |
| Location | The Eduard Biermann Auditorium, Aarhus University, Bartholins Allé 3, 8000 Aarhus C |
On Thursday 9 September at 10:30, Kristian Stær defends his PhD dissertation entitled "Follow-up on in vivo assessment of brain neurotransmitter dysfunction and microglial activation as early markers of parkinsonian disorders in patients with iRBD".
The early pathophysiological processes of alpha-synucleinopathies (ie. Parkinson's disease) are still not fully understood. Patients with isolated REM sleep behaviour disorder (iRBD), a condition with dream enactment and involuntary movement during REM sleep, are very likely to develop some form of alpha-synucleinopathy later in life, when compared to the background population. These patients, therefore, are an ideal group to investigate in order to better understand the early processes in alphasynucleinopathies, as they can be considered in a prodromal stage of these diseases.
In the current thesis, physiological changes, in the form of inflammatory changes, and changes in the activity of cholinergic and dopaminergic neurotransmitters, in the brains of iRBD patients were investigated, using PET-imaging, with the aim of evaluating their impact on the development of Parkinson's disease or related disorders.
The summary is written by the PhD student.
The defence is public and takes place in the Eduard Biermann Auditorium, Aarhus University, Bartholins Allé 3, 8000 Aarhus C. Please read the attached press release for more information.
PhD student Kristian Stær
Mail: kst@clin.au.dk