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Dose-escalated, intensified radiotherapy for high-risk head and neck squamous cell carcinoma
2021.05.27 |
| Date | Fri 11 Jun |
| Time | 14:00 — 16:00 |
| Location | The Danish Center for Particle Therapy, Aarhus University Hospital, Palle Juul-Jensens Boulevard, Aarhus N and online |
On Friday 11 June at 14:00 Mette Saksø defends her PhD dissertation entitled "Dose-escalated, intensified radiotherapy for high-risk head and neck squamous cell carcinoma".
It is possible to intensify the treatment by increasing the total dose. To spare the normal tissues, the treatment can be given i smaller portions, with less dose per fraction, but with more fractions given. This principle is called hyperfractionation. The schedule includes two daily treatments on weekdays for 5.5 weeks. Moreover, the treatment efficacy can be improved by chemotherapy given concomitant to the radiotherapy (chemo-radiotherapy).
The results of the PhD project demonstrates that such schedule is feasible and effective for locally advanced head and neck cancer in otherwise fit patients. The intensified treatment causes side effects, and should be considered only in selected patients. The PhD project futhermore explores how hypoxia-specific PET imaging prior to radiotherapy can identify patients with radiation-resistant tumors, and whether this subgroup of patients can be expected to benefit from the twice-daily, intensified schedule.
The summary is written by the PhD student.
The defence is public and is held at the Danish Center for Particle Therapy, Aarhus University Hospital, Entrance B3, Level 4, Palle Juul-Jensens Boulevard 25, 8200 Aarhus N and online. Please read the attached press release for more information.
PhD student Mette Saksø
Mail: mette.saksoe@oncology.au.dk
Phone: (+45) 78454963