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Characterization of STING-activated IRF3 and NF-κB p65 pathways at the single cell level
2020.10.28 |
| Date | Wed 25 Nov |
| Time | 14:30 — 16:30 |
| Location | Online via Zoom |
Wednesday 25 November at 14:30, Alice Pedersen defends her PhD dissertation entitled "Characterization of STING-activated IRF3 and NF-κB p65 pathways at the single cell level".
The protein STING induces the expression of antiviral type 1 interferons and pro-inflammatory cytokines through the transcription factors IRF3 and NF-kB p65, respectively, and is key for the innate immune defence against invading pathogens. However, over-activation of STING can lead to inflammatory disease. STING is currently being explored as target for immunomodulatory therapy. This requires a detailed knowledge on STING signalling. Therefore, we have characterized the STING-activated pathways at the single cell level. Interestingly, we find that the STING-activated NF-kB p65 requires IRF3. Our results will aid the investigation of STING as an immunomodulatory therapeutic target.
The summary is written by the PhD student.
The defence is public and takes place online via Zoom (https://aarhusuniversity.zoom.us/j/68077983277). Please read the attached press release for more information.
PhD student Alice Pedersen
Mail: ak@biomed.au.dk
Phone: (+45) 25305518