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Protective role of KCa3.1 ion channel blockers in animal models of acute respiratory distress syndrome
2021.03.03 |
| Date | Mon 15 Mar |
| Time | 17:00 — 19:00 |
| Location | Online |
On Monday 15 March at 17.00, Asbjørn Graver Petersen defends his PhD dissertation entitled "Protective role of KCa3.1 ion channel blockers in animal models of acute respiratory distress syndrome".
Acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in critically ill patients and is characterized by increased permeability of the alveolar-capillary barrier. The delicate structure of the alveolar-capillary barrier is tightly regulated by ion channels, but damage to the lung can disrupt these processes and lead to acute onset of pulmonary edema, hypoxemia, and a need for respiratory support. At present, effective pharmacotherapy for ARDS remains limited, but the discovery of new targets in the alveolar endothelial and epithelial barriers sparks optimism. This PhD project explores the role of two ion channels; namely, calcium-activated potassium channel of intermediate conductance (KCa3.1) and the cystic fibrosis transmembrane conductance regulator (CFTR) channel, and investigates their therapeutic potential in a series of pre-clinical studies.
The summary is written by the PhD student.
The defence is public and takes place online. Please read the attached press release for more information.
PhD student Asbjørn Graver Petersen
Mail: aspe@biomed.au.dk
Phone: (+45) 30293574
Please read full press release.