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Preclinical research in acute pulmonary embolism provides inspiration to clinical trials
2021.05.07 |
| Date | Fri 28 May |
| Time | 14:30 — 16:30 |
| Location | Online |
On Friday 28 May at 14:30, Mads Dam Lyhne defends his PhD dissertation entitled "Right ventricular function and support in acute pulmonary embolism".
Acute blood clots in the lungs, so-called pulmonary embolism, compromise the right side of the heart, as the clots obstruct the blood flow through the lungs. At the same time, the blood vessels of the lungs contract which complicates the blood flow further. Ultimately, the right side of the heart may fail which is cause of death in these patients. The main focus of treatment is solely to dissolve the blood clots. This project has investigated the strain of the right side of the heart over longer duration and investigated different strategies to support the right side of the heart. The experiments have been carried out in a very realistic animal model, which has been developed in Aarhus. The experiments showed the first 6 hours to be the most critical time window, and oxygen appears to have very beneficial effects on the function of the right side of the heart. The results may provide inspiration to trials on patients with acute pulmonary embolism.
The summary is written by the PhD student.
The defence is public and takes place online. Please read the attached press release for more information.
PhD student Mads Dam Lyhne
Mail: mads.dam@clin.au.dk
Phone: (+45) 20450486