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The interplay between fibroblast-like synoviocytes, galectin-3, galectin-9, and the T cell co-stimulatory receptor 4-1BB in rheumatoid arthritis
2021.03.11 |
| Date | Fri 26 Mar |
| Time | 15:00 — 17:00 |
| Location | Online via Zoom |
On Friday 26 March at 15:00, Morten Aagaard Nielsen defends his PhD dissertation entitled "The interplay between fibroblast-like synoviocytes, galectin-3, galectin-9, and the T cell co-stimulatory receptor 4-1BB in rheumatoid arthritis".
The interactions between immune cells and stromal cells within the RA synovium play pivotal roles in the initiation and persistence of the inflamed site. In the inflamed synovium, FLS and co-stimulatory receptors as 4-1BB modulate the immunogenic outcome. Furthermore, galectins are capable of multivalently interacting with immune and stromal cells. However, the involvement of galectins in RA pathology have not been fully characterised. Here we report, that in RA, pathological FLS, galectins, and the co-stimulatory receptor 4-1BB are all present at the site of pathology and are capable of modulating the local inflammatory outcome. The work presented in this thesis identifies a so far unrecognized mechanism by which the inflammatory drive from FLS and effector CD4+ T cells is fine-tuned by the microenvironment. Since inflammation is not generic but dependent on the local context, FLS, galectins, and 4-1BB expressed on activated T cells represent attractive and relatively site-specific therapeutic targets.
The summary is written by the PhD student.
The defence is public and takes place online via Zoom. Please read the attached press release for more information.
PhD student Morten Aagaard Nielsen
Mail: morten.a.nielsen@biomed.au.dk
Phone: (+45) 287080924