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Immunomodulatory effects of Ascaris suum products on cGAS-STING signaling
2020.10.28 |
| Date | Tue 10 Nov |
| Time | 14:00 — 16:00 |
| Location | Online via Zoom and in the Jeppe Vontilius Auditorium, Bartholins Allé 3, 8000 Aarhus C |
Tuesday 10 November at 14:00, Sidsel Dahl Andersen defends her PhD dissertation entitled "Immunomodulatory effects of Ascaris suum products on cGAS-STING signaling".
Parasitic worms are known to be true masters of host manipulation and can strongly suppress inflammatory immune responses in order to survive in the host. However, the knowledge of the specific mechanisms and molecules involved in immunomodulation by worms is limited. The focus of this study was to investigate the immunomodulatory ability of the giant roundworm, Ascaris suum, on the central immune pathway termed 'the STING pathway'. This pathway is a very important part of the innate immune response against infections, however overactive STING signalling has been linked to various chronic inflammatory disorders which currently have limited treatment options. We found that Ascaris suum effectively inhibit STING signalling by modulating signalling molecules in this pathway thereby decreasing the inflammatory response. These findings suggest that parasitic worms can hold a novel therapeutic potential for the treatment or ameliorating inflammatory disorders.
The summary is written by the PhD student.
The defence is public and takes place in the Jeppe Vontilius Auditorium, Bartholins Allé 3, 8000 Aarhus C and online via Zoom. Due to Covid-19 restrictions, participation in the physical defence is limited and is only possible upon prior agreement with the PhD student. Please read the attached press release for more information.
PhD student Sidsel Dahl Andersen
Mail: sidselandersen@clin.au.dk
Phone: (+45) 42245412