Thibaud Dieudonné has started in a postdoc position in Poul Nissen’s research group from March 2nd, 2020 to work on cryo-EM and biochemical studies of P4-ATPase lipid flippases. Thibaud will investigate the basis for lipid selectivity and the mechanism of lipid flippase activity of ATP8B1 that maintains asymmetric distributions of lipids across biomembranes in e.g. hepatocytes. ATP8B1 is affected by disease-causing mutations, post-translational modifications and regulatory elements. Thibaud will furthermore investigate how these basic mechanisms can be exploited in molecular medicine.
2020.03.03 | Karen Bech-Pedersen