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Dr. Seyed Mehdi Jafarnejad Shourkaei will present the work of his research group. The title of his talk is “Fine-tuning and quality control of mRNA translation; implications in development and disease”.
2018.10.10 |
| Date | Thu 25 Oct |
| Time | 12:00 — 13:00 |
| Location | Biochemistry Aud 6 – building 1170-347. |
The title of Dr. Seyed Mehdi Jafarnejad Shourkae's talk is “Fine-tuning and quality control of mRNA translation; implications in development and disease”.
Abstract
The synthesis of full-length, correctly folded proteins is crucial for maintaining the healthy state of a cell. Cryptic polyadenylation within coding sequences or incompletely removed introns produce aberrant mRNA transcripts. Production of such defective mRNAs is rather common in cells, although the majority of them are cleared within the nucleus. However, in certain cell types and stress conditions mRNA processing is less stringent. Translation of abberant mRNAs may result in proteins prone to malfunction and deleterious effects on cells. To mitigate these errors, cells have evolved the ribosome-associated quality-control (RQC) mechanisms that recognize and degrade aberrant mRNAs, such as those with premature poly(A) sequence within their coding region, and their resulting nascent proteins. This presentation will describe a novel mechanism that monitors mRNA translation and trigers ribosome stalling and RQC.
Venue
The seminar will be held at 12:00 pm in the Biochemistry Aud 6 – building 1170-347.
The talk will last for 45 min followed by 15 minutes of discussion.
Sign-up
It is possible to sign-up for a free sandwich here.
Please note that the deadline for the sandwich sign-up is Tuesday 23 October.
Biomedicine seminar organizing committee
Line Reinert
Martin Thomsen
Søren Degn
Mikkel Vendelbo