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Circulating cell-free DNA in patients with hepatocellular carcinoma or neuroendocrine tumors
2021.01.04 |
| Date | Fri 08 Jan |
| Time | 13:00 — 15:00 |
| Location | Online via Zoom |
On Friday 8 January at 13.00, Stine Karlsen Oversø defends her PhD dissertation entitled "Circulating cell-free DNA in patients with hepatocellular carcinoma or neuroendocrine tumors".
There is an increasing interest in investigating blood-based biomarkers in relation to early detection of cancer, monitoring of treatment responses, prognosis and the ability to personalise treatment. A new PhD project from Aarhus University, Health has examined cell-free DNA in blood as a possible marker for prognosis and monitoring of treatment in the two cancers, primary liver cancer and neuroendocrine tumors. The project INVESTOGATED a widespread mutation (TERT), found in primary liver cancer, and observed that patients who have circulating cell-free DNA in the blood carrying this mutation (44%) have a worse prognosis than patients who do not have this mutation in the blood. The project also examined patients who had cirrhosis of the liver without cancer, and none of these patients had the mutation in their blood. In addition, the project assesed whether it was possible to increase the detection rate of another significant mutation seen in primary liver cancer by analysing both tissue from the cancer and blood. The studies indicate that in a future with a wide range of treatments, it is possible to personalise treatment with the help of analyses of tumor mutations in the blood.
The summary is written by the PhD student.
The defence is public and takes place online via Zoom (https://aarhusuniversity.zoom.us/j/61476523994). Please read the attached press release for more information.
PhD student Stine Karlsen Oversø
Mail: stinkarl@rm.dk
Phone: (+45) 22793193