High Resolution-peripheral Quantitative Computed Tomography and Erosive Rheumatoid Arthritis

2021.05.12 | Graduate School of Health

On Friday 21 May at 13:00, Rasmus Klose Jensen defends his PhD dissertation entitled "High Resolution-peripheral Quantitative Computed Tomography and Erosive Rheumatoid Arthritis".

Rheumatoid arthritis (RA) is the most common chronic autoimmune joint disease. The disease is chronic, and even patients in treatment with disease-modifying anti-rheumatic drugs experience periods with inflammatory flare-ups. The inflammation of the joints can result in progressive structural damage to the joints. Bone erosions are a hallmark in RA. Conventional radiographs are presently the gold standard for diagnosing and tracing bone erosions in patients with RA. The modality is used in clinical practice and in clinical trials for evaluating the efficiency of treatments. However, conventional radiography is not sufficiently sensitive, as the sensitivity for detecting erosions is low. Therefore, more sensitive imaging is needed. High Resolution - peripheral Quantitative Computed Tomography (HR-pQCT) imaging has a superior resolution to all other imaging modalities in vivo. Consequently, the modality has been proposed as a possible substitution for conventional radiography. The PhD project includes the largest cohort of patients with rheumatoid arthritis examined for erosive disease with HR-pQCT imaging at present. The PhD project investigates the diagnostic accuracy of HR-pQCT scan and full radiographic examination in relation to classifying whether patients with rheumatoid arthritis have erosive disease.

The summary is written by the PhD student.    

The defence is public and takes place online. Please read the attached press release for more information.

Contact:

PhD student Rasmus Klose Jensen

Mail: raujen@rm.dk

Phone: (+45) 31672106

Read full press release